Essential amino acids are important nutrients that must be consumed directly because they cannot be produced naturally by the body. There are nine essential amino acids: histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine. These compounds are fundamental components of all of the body's cells, but are particularly needed by the muscles.
What they're used for
Nearly everyone knows that they need to eat protein, but may think of it as a singular thing that is directly used by the body. Protein is actually a complex combination of several types of amino acids, including these nine, plus those that are either not needed on a regular basis, or those that can be synthesized by the body.
Essential amino acids are part of any food that contains protein. But different sources of protein vary in the amount of each essential amino acid they contain. For example, whitefish is much richer in histidine than turkey, but is relatively poor in tryptophan.
Isoleucine, leucine, and valine are known as branched-chain amino acids (BCAAs). These have some specific medical uses as supplements, but are also taken by bodybuilders as a nutritional supplement to reduce catabolism on days of low food intake. They're also taken during workouts to quicken protein uptake.
Muscle protein is the most important protein for athletes. A supplement of whey or soy protein powder that contains branched-chain amino acids (usually along with a mix of other ingredients) is commonly used to extend and improve training regimens, as well as increase athletic endurance.
Amino acid breakdown
The lack of even one essential amino acid can inhibit protein processing and lead to muscle breakdown, fatigue, overall weakness, and suppression of the immune system.[1]
Each one also has its own unique benefits:
Histidine
Histidine is converted by the body to histamine, a powerful vasodilator that plays a role in digestion and central nervous system health. A deficiency in histidine can result in digestive issues, anemia, nerve deafness, hearing loss, and worsen symptoms associated with rheumatoid arthritis.[2,3]
Isoleucine
Isoleucine's biggest role is to promote glucose uptake during exercise, but it also aids in muscle protein synthesis (though, to a lesser degree than leucine).[4] Deficiency induces symptoms similar to those of hypoglycemia and hastens the breakdown of muscle tissue.[5]
Leucine
Leucine is the virtual inverse of isoleucine in terms of benefits. It primarily facilitates muscle protein synthesis, but is also somewhat useful in promoting glucose uptake.[6] Deficieny induces symptoms similar to those of isoleucine.[5]
Lysine
Lysine plays a key role in calcium absorption and converting fatty acids into energy. Studies also support the idea that it may help to control herpes simplex virus outbreaks.[7,8] Lysine deficiency may contribute to anxiety and stress.[9,10]
Methionine
Methionine is put to use in repairing and rebuilding kidney cells. A deficiency can lower urine pH balance and promote kidney stones and urinary tract infections.[11] It's also necessary for the formation of a number of compounds, including creatine, taurine, and lecithin.[12]
Phenylalanine
Phenylalanine promotes mood regulation. Studies have shown that supplementation may alleviate symptoms of depression.[13, 14]
Threonine
Threonine plays a major role in supporting the immune system, as well as formation of tooth enamel and collagen.[15]
Tryptophan
Tryptophan is a necessary precursor for the production of auxin, niacin, and serotonin.[16] Supplements often promote it as a sleep aid, but evidence of the amino acid directly causing fatigue is not conclusive (drowsiness after eating meats rich in tryptophan may actually be due to seratonin increase from the flood of carbohydrates that usually accompany such meals).[17]
Valine
As with the other BCAAs, valine promotes muscle protein synthesis and glucose uptake. But it is also necessary for cognitive and nervous system function and regulation of the immune system.[18]
Recommended dosage
The World Health Organization (WHO) charts established daily requirements for each of the essential amino acids. See the table below for proper dosing information.[23]
Forms
Most of the essential amino acids can be purchased individually as supplements, but the most common form of supplementation for athletes and bodybuilders is the all-inclusive BCAA supplement. At the very least, a BCAA supplement will contain the three branched-chain acids that are most key to muscle development: leucine, isoleucine, and valine.
BCAA supplements are most commonly sold as a powder, but there are a handful of pill and capsule options.
Side effects
Since essential amino acids are a dietary requirement, they do not cause side effects on their own. Taking very large doses of a BCAA powder can cause gastrointestinal discomfort.[19] People with certain medical conditions should not supplement with BCAA powder (see Warnings below).
Food sources
Foods that are rich in protein tend to be packed with essential amino acids. Meat, eggs, poultry, and fish contain either all or nearly all of the essential amino acids in one serving. Vegetarians and vegans need to turn to beans to get a similarly rich dose, particularly soy, kidney, and pinto beans. Mixed nuts (five or more types) will also provide nearly all of the essentials. A number of vegetables provide complete proteins, albeit in smaller amounts. Corn, tomatoes, potatoes, green peppers, celery, cucumbers, iceberg lettuce, broccoli, and carrots contain at least a small amount of each of the nine essentials.
Considerations
Always consult with a doctor before starting a new program of supplementation, or using supplements to ramp up an exercise routine. The FDA does not regulate essential amino acids. While no upper limit for consumption has been established, toxicity is possible in very large amounts.
Warnings
While most people can consume the amino acids in protein without adverse side effects, supplementation with a BCAA powder or pills is not advised for people with the following conditions:
- Amyotrophic Lateral Sclerosis (ALS, Lou Gehrig's disease): Several studies have shown that BCAA supplementation may improve the symptoms of ALS, but in one study, the number of deaths increased slightly versus a placebo. There is too little information at present to determine if BCAA supplementation consistently helps or exacerbates the disease.[20,21]
- Ketoaciduria (maple syrup urine disease): Ketoaciduria is a result of toxins from BCAAs accumulating without proper processing in the body. Supplementation will exacerbate the condition.[22]
- Parkinson's disease: Patients taking levodopa should not supplement with BCAAs since it interferes with the effectiveness of the medication.
Where to buy
Essential amino acids and all-inclusive BCAA supplements can be found right here at PricePlow, and at 30% to 50% off of retail prices to boot. Save on sales tax (where applicable) and let PricePlow find the best price and latest price reductions so you can focus on your workout.
What we like
PNI's MyoACTIV EAA's is our preferred product if you're looking for a full spectrum of essential aminos. It provides the three BCAAs in a formula that promotes anabolism and focuses on muscle growth and recovery. It's sold in orange and watermelon flavor.
Purple Wraath, from Controlled Labs, provides the complete range of essential amino acids with the addition of the PurplEndurance Complex for maximizing fat loss and lean gains — beta-alanine, citrulline malate, betaine anhydrous, ginger (from root), and L-norvaline.
Cellucor's Alpha Amino focuses on workout recovery and athletic endurance by providing nine micronized essential amino acids along with taurine and chia seed extract, all in a package that is carbohydrate and sugar-free. Also, it comes in a choice of great fruit flavors.
References
- World Health Organization; "Protein and amino acid requirements in human nutrition;" 2007
- Maeda, K, et. al.; Experimental Hematology; "Induction of L-histidine decarboxylase in a human mast cell line, HMC-1;" April 1998
- Pinals, R, et. al.; Journal of Rheumatology; "Treatment of RA with L-Histidine: : a randomized, placebo-controlled, double-blind trial;" Winter 1977
- Doi, M, et. al.; Journal of Nutrition; "Isoleucine, a blood glucose-lowering amino acid, increases glucose uptake in rat skeletal muscle in the absence of increases in AMP-activated protein kinase activity;" September 2005
- Doi, M, et. al.; American Journal of Physiological Endocrinology and Metabolism; "Hypoglycemic effect of isoleucine involves increased muscle glucose uptake and whole body glucose oxidation and decreased hepatic gluconeogenesis;" February 2007
- Shimomura, Y, et. al.; American Society for Nutrition; "Nutraceutical Effects of Branched-Chain Amino Acids on Skeletal Muscle;" February 2006
- Gaby, AR; Alternative Medicine Review; "Natural remedies for Herpes simplex;" June 2006
- Singh, BB, et. al.; Alternative Medicine Review; "Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes;" June 2005
- Smigra, et. al.; Proceedings of the National Academy of Sciences; "Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria;" June 2004
- Smigra, et. al.; The Journal of Nutrition; "Dietary L-Lysine Deficiency Increases Stress-Induced Anxiety and Fecal Excretion in Rats;" December 2002
- Lieber, C; American Society for Clinical Nutrition; "S-Adenosyl-l-methionine: its role in the treatment of liver disorders;" 2002
- Skiba, WE, et. al.; Journal of Biological Chemistry; "Human hepatic methionine biosynthesis: Purification and characterization of betaine:homocysteine S-methyltransferase;" December 1982
- Beckmann, H, et. al.; Journal of Neural Transmission; "DL-Phenylalanine in depressed patients: an open study;" 1977
- Beckmann, H, et. al.; Arch Psychiatr Nervenkr; "DL-phenylalanine versus imipramine: a double-blind controlled study;" July 1979
- Kamata, T, et. al.; Journal of Biological Chemistry; "Critical Threonine and Aspartic Acid Residues within the I Domains of Beta 2 Integrins for Interactions with Intercellular Adhesion Molecule 1 (ICAM-1) and C3bi;" May 1995
- Fernstrom, JD,; Physiological Review; "Role of precursor availability in control of monoamine biosynthesis in brain;" April 1983
- Wurtman, RJ, et. al.; American Journal of Clinical Nutrition; "Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios;" January 2003
- Yoshizawa, F; Journal of Pharmacological Science; "New therapeutic strategy for amino acid medicine: notable functions of branched chain amino acids as biological regulators;" January 2012
- "Conditioning for Strength and Human Performance;"by T. Jeff Chandler and Lee E. Brown; Lippincott Williams & Wilkins; March 2007
- Testa, D, et. al.; Journal of Neurology; "Branched-chain amino acids in the treatment of amyotrophic lateral sclerosis;" 1989
- Tandan, R, et. al.; Neurology; "A controlled trial of amino acid therapy in amyotrophic lateral sclerosis: I. Clinical, functional, and maximum isometric torque data;" November 1996
- Pontoni, G, et. al.; Amino Acids; "Diet treatment of branched chain ketoaciduria studied by proton magnetic resonance spectroscopy;" March 1996
- Institute of Medicine; "Dietary Reference Intakes: Macronutrients"
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Dec 29, 2023 YouTube Video
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Dec 27, 2023 Product News
JaktRX BCAA Energy was created.
Category: BCAA Powder -
Dec 27, 2023 Product News
Swolverine INTRA was created.
Category: Intra Workout -
Dec 27, 2023 TikTok Video
@MuscleTech EAAs making a comeback? -
Dec 26, 2023 Product News
JNX Sports The Jinx was created.
Categories: BCAA Powder, Electrolytes -
Dec 26, 2023 Product News
FNX Reburst was created.
Categories: Electrolytes, Intra Workout -
Dec 26, 2023 Product News
FNX Recover was created.
Category: BCAA Powder -
Dec 26, 2023 Product News
NOCCO BCAA RTD was created.
Category: BCAA -
Dec 26, 2023 Product News
Swolverine BCAA 2:1:1 was created.
Category: BCAA Powder -
Dec 21, 2023 Blog Post
MuscleTech Platinum 100% EAA+ Amplify Recovery and Rehydrate
MuscleTech just launched a premium essential amino acid product in their new Platinum 100% EAA, providing a complete amino acid profile paired with hydration. -
Dec 21, 2023 Product News
PVL EAA + BCAA Complete was created.
Categories: BCAA Powder, Essential Amino Acids -
Dec 13, 2023 YouTube Video
It's Mango Time! Nutrex EAA+ Hydration Flavor Review -
Dec 10, 2023 Product News
AllMax Nutrition EAA was created.
Category: Essential Amino Acids -
Nov 30, 2023 Product News
Muscle Pharm EAA Recovery + BCAA was created.
Categories: BCAA Powder, Essential Amino Acids -
Nov 29, 2023 YouTube Video
Amino Acid Supplements for Athletes in 1 Minute: Fresh Supps Amino -
Nov 27, 2023 Product News
PEScience Introse was created.
Category: Intra Workout -
Nov 21, 2023 Blog Post
Fresh Supps Amino: Essential Amino Acids (EAAs) That Keep it Fresh
Fresh Supps Amino is a full-spectrum EAA/BCAA supplement with some added Concentrace-AC for mineral support. With this, you can keep workouts Fresh -
Nov 16, 2023 Product News
Performance Inspired BCAA with Energy was created.
Categories: BCAA Powder, Energy & Endurance -
Nov 11, 2023 Product News
Like a Pro Supplements BCAA+EAA V2 was created.
Categories: BCAA Powder, Electrolytes, Essential Amino Acids -
Nov 09, 2023 Product News
MuscleTech Platinum 100% EAA+ was created.
Categories: Electrolytes, Essential Amino Acids, Intra Workout -
Nov 04, 2023 Product News
Morphogen Nutrition PUMP was created.
Category: Intra Workout -
Oct 05, 2023 Product News
BodyTech Altered Amino - EAA & Test Booster was created.
Categories: Essential Amino Acids, Testosterone Boosters -
Sep 07, 2023 Product News
VMI Sports Aminogex EAAs/BCAAs was created.
Categories: BCAA Powder, Essential Amino Acids -
Sep 07, 2023 Product News
EVLution Nutrition BCAA1000 was created.
Category: BCAA Pills -
Sep 06, 2023 Product News
EndurElite Fuel Elite was created.
Category: Intra Workout -
Aug 25, 2023 YouTube Video
Whey Protein Innovation with Arla Foods Ingredients | Episode 108 -
Aug 25, 2023 Product News
Podium Nutrition Hydro + Salt BCAA was created.
Category: BCAA Powder -
Aug 24, 2023 Blog Post
It’s Mango Time! Nutrex Releases New EAA+ Hydration Flavor
Nutrex EAA+ Hydration has a new MANGO flavor named "It's Mango Time", which came just after the labeling/artwork changes to their new branding! -
Aug 22, 2023 Product News
6AM Run HYDRA BLAST was created.
Categories: BCAA Powder, Electrolytes -
Aug 22, 2023 Product News
6AM Run MARATHON was created.
Category: Essential Amino Acids -
Aug 18, 2023 Blog Post
Nutrex EAA+ Hydration Gets Bold 2023 Branding
Nutrex EAA+ Hydration has been rebranded with the new 2023 look, but has the same great EAA/BCAA/Hydration formula as it has since 2019! -
Aug 16, 2023 Product News
Like a Pro Supplements Glycotrix V3 was created.
Category: Intra Workout -
Aug 08, 2023 Blog Post
MuscleTech Manufacturing: Worldwide Facilities for International Products
Did you know that MuscleTech manufactures products in the country/geography they sell them in? This leads to better compliance... and local flavors! -
Aug 04, 2023 YouTube Video
How to Sell a Supplement Brand | Mike McCandless | PricePlow Ep. 106 -
Aug 04, 2023 Blog Post
Mike McCandless: How to Sell a Supplement Brand | Episode #106
Mike McCandless is the founder of Scivation, who created Xtend and sold the business to Nutrabolt. He explains how to sell a business on PricePlow -
Aug 04, 2023 TikTok Video
HOW DO YOU SELL A SUPPLEMENT BRAND? Mike Mccandless, founder of Scivation, joins us to discuss... -
Jul 16, 2023 YouTube Video
Bodybuilding.com Elite Thermo + BCAA Perfect for Fasted Cardio -
Jul 16, 2023 TikTok Video
Repeat: BCAAs are NOT for BUILDING Muscle, they're to PRESERVE it, especially for stuff like... -
Jul 06, 2023 Product News
Mammoth Supplements EAA9 was created.
Category: Essential Amino Acids -
Jul 05, 2023 Blog Post
Raw Nurition Beta Alanine: Boost Endurance with Carnosine Precursors
Raw Nutrition has a new Beta Alanine supplement, but it's no ordinary BA supp -- it also has L-Histidine and added electrolytes in phosphate form! -
Jul 03, 2023 Blog Post
4 For the 4th: Musclesport Launches 4 Flavors for 4th of July 2023
Musclesport celebrates 4th of July 2023 with 4 different flavors, two in Lean Whey (Apple Pie a la Mode and Patriot Cake) and two in BCAA Revolution! -
Jun 21, 2023 Product News
EHP Labs Beyond BCAA + EAA was created.
Categories: BCAA Powder, Essential Amino Acids -
Jun 19, 2023 Blog Post
Bodybuilding.com Elite Thermo + BCAA: Burn Fat and Recover
Bodybuilding.com's Elite Thermo + BCAA powder that helps you recover and burn fat at the same time, thanks to its use of MitoBurn from NNB Nutrition -
Jun 16, 2023 Product News
Swanson Lysine Lip Balm was created.
Categories: Lip Balm, Lysine -
Jun 15, 2023 Product News
Swanson Essential Amino Acid Complex was created.
Category: Essential Amino Acids -
Jun 13, 2023 Blog Post
Primeval Labs EAA Max Energy: Amino Acids with a Kick
Primeval Labs EAA MAX Energy takes their great tasting aminos and adds 50mg caffeine to give you an extra boost during your workout or activity. -
Jun 12, 2023 Product News
BodyTech Elite Ultimate BCAA was created.
Category: BCAA Powder -
Jun 12, 2023 Product News
BodyTech BCAA was created.
Category: BCAA Pills -
Jun 12, 2023 Product News
BodyTech Instantized BCAA was created.
Category: BCAA Powder -
Jun 12, 2023 Product News
BodyTech BCAA + Glutamine was created.
Categories: BCAA Powder, Glutamine Powder
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Essential Amino Acid Price Alerts
The following price alerts are still active:
- Apr 08, 2025GHOST BCAA 30 Servings (only Sour Patch Kids Blue Raspberry, Sour Patch Kids RedBerry) dropped by 20% to $22.40 at Ghost Lifestyle
- Mar 20, 2025EVLution Nutrition BCAA 5000 30 Servings (only Furious Grape) dropped by 37.2% to $13.19 at iHerb.com
- Aug 23, 2024GHOST BCAA 30 Servings (only Lemon Crush, Sour Patch Kids Watermelon) dropped by 20% to $22.40 at Ghost Lifestyle
- Jan 10, 2024PEScience Amino IV 60 Servings dropped by 9.1% to $42.50 at PEScience
- Jun 22, 2023PEScience Amino IV 30 Servings (only Orange Dreamsicle) dropped by 15% to $25.50 at PEScience
Sign up for future Essential Amino Acid deals and coupons!
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Essential Amino Acid Reviews & Videos
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Apr 14, 2025MitoPrime Ergothioneine: The Longevity Vitamin Backed By 3 Major Scientific Studies #healthspan
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Apr 10, 2025Big Things Can Come in Little Sizes | NNB's MitoPrime + NutriScience's SalidroPure! #supplements
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Mar 16, 2025Basic MASS: When Simple Nutrition Equals Serious Gains
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Mar 06, 2025Ghost Intra Lemon Lime: Fresh Citrus Flavor for Complete Workout Support
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Mar 06, 2025@ghostlifestyle just dropped Lemon Lime Intra and it's Full 9-EAA profile (not just BCAAs!) ...
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Feb 14, 2025MuscleSport Clean Whey Naturals Strawberry Ice Cream
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Feb 13, 2025MuscleSport Clean Whey Naturals Chocolate Ice Cream
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Feb 13, 2025NNB Nutrition's DL185 Dileucine Shows Significant Strength Gains in New PLOS ONE Study
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Feb 12, 2025Titan Nutrition KRE-EX Unrivaled Brings Back Full-Spectrum Pre-Workout Era
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Feb 11, 2025The Basic Essentials from Basic Supplements (Glutamine, Creatine, and BCAAs)
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Feb 03, 2025Modere's New Magnesium Blend for Optimal Performance
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Jan 28, 2025Why Spoken Aminos + ATP Goes Beyond Basic Amino Acids
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Jan 28, 2025Amino acids are back but not like before Spoken Aminos + ATP adds PeakATP for stim-free energy...
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Jan 16, 2025Basic Supplements Goes Full Transparency with Third-Party Lab Test Results
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Dec 18, 2024Fresh Supps Unwraps Kringle Candy for Christmas 2024
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Nov 23, 2024Xtend BCAAs Airheads Taste Like The Real Thing?
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Nov 22, 2024@drinkxtend BCAAs airheads taste like the real thing?
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Nov 01, 2024Synnovo® by INNOBIO: Raising the Bar for Amino Acids
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Oct 17, 2024Musclesport Mass Revolution: A Complete Mass Gainer for Easy Bulking
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Sep 16, 2024What Makes Ghost SLEEP Different from Other Sleep Aids?
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Sep 12, 2024The Return of GHOST x Sour Strips Rainbow Flavor Collab, in FIVE Different Products!
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Jul 17, 2024Dan Lourenço: Ghost Legend V4 and the Ghost 100 Year Plan | PricePlow 143
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Jul 12, 2024Musclesport Amino + Hydration: EAA Formula in Patriot Pop!
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Jul 12, 2024Creatine monohydrate is great, but what about creatine with Electrolytes, Taurine, and AstraGin...
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Jul 10, 2024MuscleTech Platinum 100% EAA+ Amplify Recovery and Rehydrate
-
Jul 10, 2024MuscleTech's Platinum 100% EAA+ Amino Acids + Electrolytes aids recovery and muscle sustainment...
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Jun 06, 2024Ghost INTRA: Hydration, Aminos, and Workout Nootropics
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Jun 06, 2024Ghost INTRA: Hydration, Aminos, and Workout Nootropics!
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Jun 01, 2024Ryan Garcia (Boxer) Blames NutraBio for Failed Drug Test?! (Ostarine)
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May 09, 2024New Muscle Builder? DL185 by NNB Nutrition!
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Feb 06, 2024What is PEPTIDE 185 by MuscleTech?! Dileucine with Raza Bashir and Shawn Wells | Episode 123
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Jan 22, 2024PEPTIDE 185! MuscleTech's New DILEUCINE Muscle Builder
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Jan 05, 2024Higher-Leucine Protein! BLG-100 (Beta-Lactoglobulin) by Arla
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Jan 03, 2024PRIME HYDRATION KILLER?! Inspired Nutra Endless YUTH RTD
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Dec 29, 2023MuscleTech Plaitnum 100% EAA+ Explained
-
Dec 27, 2023@MuscleTech EAAs making a comeback?
-
Dec 13, 2023It's Mango Time! Nutrex EAA+ Hydration Flavor Review
-
Nov 29, 2023Amino Acid Supplements for Athletes in 1 Minute: Fresh Supps Amino
-
Aug 25, 2023Whey Protein Innovation with Arla Foods Ingredients | Episode 108
-
Aug 04, 2023How to Sell a Supplement Brand | Mike McCandless | PricePlow Ep. 106
-
Aug 04, 2023HOW DO YOU SELL A SUPPLEMENT BRAND? Mike Mccandless, founder of Scivation, joins us to discuss...
-
Jul 16, 2023Bodybuilding.com Elite Thermo + BCAA Perfect for Fasted Cardio
-
Jul 16, 2023Repeat: BCAAs are NOT for BUILDING Muscle, they're to PRESERVE it, especially for stuff like...
-
May 30, 2023Jersey Shore Supplements to AstroFlav: Brian Tweer & Brady Adamson (PricePlow 095)
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May 26, 2023Animal Juiced Aminos: Boosted with Hydration & Performance Ingredients
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May 19, 2023MuscleTech International: When it's NOT Made in America...
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May 06, 2023Muscletech Amino Build - French Canadian Version!
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Apr 28, 2023HMB Supplements: The FULL Story. Shawn Baier | PricePlow Podcast 093
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Apr 24, 2023Animal JUICED Aminos: Now with Electrolytes
-
Apr 21, 2023Primeval Labs EAA Max Gets a Touch-Up with Sour Apple Candy!
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