Phenylethylamine Is No Longer Made but you can still buy Ephedrine HCL tablets
Phenethylamine phenethylamine, or phenylethylamine is an organic compound and a natural monoamine alkaloid, a trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Phenylethylamine functions as a neuromodulator or neurotransmitter in the mammalian central nervous system. It is biosynthesized from the amino acid phenylalanine by enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation. It is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, orally ingested phenethylamine experiences extensive first-pass metabolism by monoamine oxidase B (MAO-B), which turns it into phenylacetic acid. This prevents significant concentrations from reaching the brain in low doses. The group of phenethylamine derivatives is referred to as the phenethylamines. Substituted phenethylamines, substituted amphetamines, and substituted methylenedioxyphenethylamines (MDxx) are a series of broad and diverse classes of compounds derived from phenethylamine that include stimulants, psychedelics, and entactogens, as well as anorectics, bronchodilators, decongestants, and antidepressants, among others.
Chronic stress has long been held responsible as a primary contributor to neurotransmitter imbalance. Stress, both physical and emotional can lead to increased neurotransmitter excretion by the neurons in order to help the body cope with the situation. Acute stress is generally well tolerated by the body and normally does not lead to significant neurotransmitter imbalances. In contrast however, chronic stress will tax the nervous system and over time deplete neurotransmitter supplies. Poor dietary habits may also contribute to neurotransmitter imbalance, particularly when coupled with stress. The production of these brain chemicals is dependant upon sufficient levels of amino acid precursors. Diets which are low in protein may limit the supply of these amino acids.
In the situation where the neurotransmitter concentrations are too low, they will be unable to simultaneously engage enough of the post synaptic receptor sites needed to continue a message. This disrupts signal transduction and important messages may not be sent. Another common situation is that the levels of certain neurotransmitters become too high and as such, the frequency of inappropriate signals that are relayed increases. This increased signaling can be described as “static” and make it difficult for the neurons to discern between incoming signals that are important against those background signals that should be ignored.
Why choose nutrients over drugs?
The pharmaceutical industry has developed hundreds of drugs designed to treat a whole host of mood disorders. The vast majority of these drugs work directly upon the function of neurotransmission. A major drawback of these drugs however, is that they only affect the transportation or release of existing pools of neurotransmitters in the body. If the diet does not provide sufficient amounts of neurotransmitter precursors, then there may not be enough neurotransmitters to properly relay signals within the nervous system, even if the drugs are used. More than just a PEA-sized neurochemical In many previous Nutritional News articles, we have addressed some of the major players involved in mood disorders– such as serotonin, dopamine, glutamate, gaba, norepinephrine and epinephrine. In this issue, we would like to focus on phenylethylamine (PEA) which is a stimulatory neurotransmitter that increases mental activity and alertness. PEA is classified as a minor neurotransmitter, this means that there is less of it; however it does not mean that it has any less significance than some of the other more well known and studied neurotransmitters. Early findings originally suggested that PEA was only a neuromodulator in that it altered the function or release of the major neurotransmitters, however in 2001 scientists discovered a receptor specific for PEA. 1 This then meant that classification for PEA changed from a neuromodulator to neurotransmitter as PEA has the potential to relay messages on its own. Where does it come from? PEA is synthesized from the amino acid phenylalanine via aromatic amino acid decarboxylase. It can be seen in the diagram below that phenylalanine, tyrosine and L-DOPA are all amino acids which can be used to support catecholamine synthesis. Phenylalanine however, will also increase PEA levels while the other amino acids further downstream, will not affect PEA. Understanding of this biochemical pathway becomes very important when choosing appropriate nutritional interventional therapies.
As a dietary supplement consume 1-2 servings per day. Consume one serving prior to breakfast. Consume a second serving prior to another meal or 30 minutes prior to exercise. Vegetable-derived capsules from highly purified plant cellulose, Natural Flow Agents (purified plant cellulose, L-Leucine and/or L-Valine. Not intended for use by persons under the age of 18. If you are pregnant or nursing or are taking any prescription medications, consult your healthcare professional before using this or any other dietary supplement product. Immediately discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store in a cool, dry place and avoid excessive heat.
Phenethylamine phenethylamine, or phenylethylamine is an organic compound and a natural monoamine alkaloid, a trace amine, and also the name of a class of chemicals with many members well known for psychoactive drug and stimulant effects. Phenylethylamine functions as a neuromodulator or neurotransmitter in the mammalian central nervous system. It is biosynthesized from the amino acid phenylalanine by enzymatic decarboxylation. In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, especially after microbial fermentation. It is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, orally ingested phenethylamine experiences extensive first-pass metabolism by monoamine oxidase B (MAO-B), which turns it into phenylacetic acid. This prevents significant concentrations from reaching the brain in low doses. The group of phenethylamine derivatives is referred to as the phenethylamines. Substituted phenethylamines, substituted amphetamines, and substituted methylenedioxyphenethylamines (MDxx) are a series of broad and diverse classes of compounds derived from phenethylamine that include stimulants, psychedelics, and entactogens, as well as anorectics, bronchodilators, decongestants, and antidepressants, among others.
Chronic stress has long been held responsible as a primary contributor to neurotransmitter imbalance. Stress, both physical and emotional can lead to increased neurotransmitter excretion by the neurons in order to help the body cope with the situation. Acute stress is generally well tolerated by the body and normally does not lead to significant neurotransmitter imbalances. In contrast however, chronic stress will tax the nervous system and over time deplete neurotransmitter supplies. Poor dietary habits may also contribute to neurotransmitter imbalance, particularly when coupled with stress. The production of these brain chemicals is dependant upon sufficient levels of amino acid precursors. Diets which are low in protein may limit the supply of these amino acids.
In the situation where the neurotransmitter concentrations are too low, they will be unable to simultaneously engage enough of the post synaptic receptor sites needed to continue a message. This disrupts signal transduction and important messages may not be sent. Another common situation is that the levels of certain neurotransmitters become too high and as such, the frequency of inappropriate signals that are relayed increases. This increased signaling can be described as “static” and make it difficult for the neurons to discern between incoming signals that are important against those background signals that should be ignored.
Why choose nutrients over drugs?
The pharmaceutical industry has developed hundreds of drugs designed to treat a whole host of mood disorders. The vast majority of these drugs work directly upon the function of neurotransmission. A major drawback of these drugs however, is that they only affect the transportation or release of existing pools of neurotransmitters in the body. If the diet does not provide sufficient amounts of neurotransmitter precursors, then there may not be enough neurotransmitters to properly relay signals within the nervous system, even if the drugs are used. More than just a PEA-sized neurochemical In many previous Nutritional News articles, we have addressed some of the major players involved in mood disorders– such as serotonin, dopamine, glutamate, gaba, norepinephrine and epinephrine. In this issue, we would like to focus on phenylethylamine (PEA) which is a stimulatory neurotransmitter that increases mental activity and alertness. PEA is classified as a minor neurotransmitter, this means that there is less of it; however it does not mean that it has any less significance than some of the other more well known and studied neurotransmitters. Early findings originally suggested that PEA was only a neuromodulator in that it altered the function or release of the major neurotransmitters, however in 2001 scientists discovered a receptor specific for PEA. 1 This then meant that classification for PEA changed from a neuromodulator to neurotransmitter as PEA has the potential to relay messages on its own. Where does it come from? PEA is synthesized from the amino acid phenylalanine via aromatic amino acid decarboxylase. It can be seen in the diagram below that phenylalanine, tyrosine and L-DOPA are all amino acids which can be used to support catecholamine synthesis. Phenylalanine however, will also increase PEA levels while the other amino acids further downstream, will not affect PEA. Understanding of this biochemical pathway becomes very important when choosing appropriate nutritional interventional therapies.
As a dietary supplement consume 1-2 servings per day. Consume one serving prior to breakfast. Consume a second serving prior to another meal or 30 minutes prior to exercise. Vegetable-derived capsules from highly purified plant cellulose, Natural Flow Agents (purified plant cellulose, L-Leucine and/or L-Valine. Not intended for use by persons under the age of 18. If you are pregnant or nursing or are taking any prescription medications, consult your healthcare professional before using this or any other dietary supplement product. Immediately discontinue use and consult your doctor if any adverse reactions occur. Keep out of reach of children. Store in a cool, dry place and avoid excessive heat.
