Vitamin A is a fat-soluble vitamin reported to facilitate eye, skin, immune system and other bodily functions and development. It was originally named "Fat-Soluble A", but renamed to "Vitamin A" in 1920.[4]
There are two different types of vitamin A: preformed and provitamin. The former is found in eggs, fish, and dairy, while the latter is found in fruits, vegetables (orange colors and darker colors) and other plant-based foods.[1,3] It also can be synthesized in a lab.[2]
Vitamin A Deficiency and Toxicity
Vitamin A deficiency is very uncommon in the United States and other industrialized nations. Long-term deficiency may lead to dry eye and night blindness.[1,3]As it is a fat-soluble molecule, it's important to be highly aware of long-term accumulation and toxicity.[5]
Vitamin A is also antagonistic to vitamin D in animal models.[6]
Additionally, people with liver disease who also drink excessive amounts of alcohol may have a better chance of suffering liver damage from consuming vitamin A supplements.[1]
For these reasons, we express caution when discussing vitamin A supplements.
References
- "Vitamin A (Retinol);" MayoClinic.com
- "Vitamin A;" WebMD.com
- "Vitamin A;" Dietary Supplement Fact Sheet; Office of Dietary Supplements; National Institutes of Health
- Drummond, Cecil Jack; "The Nomenclature of the So-Called Acceassory Food Factors (Vitamins)."; The Biochemical Journal vol. 14,5 (1920): 660. doi:10.1042/bj0140660; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1258930/pdf/biochemj01182-0127.pdf
- Olson, Jazmine M., et al. "Vitamin A Toxicity." StatPearls, StatPearls Publishing, 8 August 2022; https://pubmed.ncbi.nlm.nih.gov/30422511/
- Rohde, Cynthia M., et al. "Vitamin a Antagonizes the Action of Vitamin D in Rats." The Journal of Nutrition, vol. 129, no. 12, 1 Dec. 1999, pp. 2246–2250, 10.1093/jn/129.12.2246; https://academic.oup.com/jn/article/129/12/2246/4722077
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